David J Rawlings, MD

David J Rawlings, MD

Specialties

  • Children's Title: Director, Center for Immunity and Immunotherapies, Seattle Children’s Research Institute; Director, Program for Cell and Gene Therapy, Seattle Children’s Research Institute; Chief, Division of Immunology, Seattle Children's Hospital
  • Academic Title: Professor, Pediatrics
  • Research Title: Director, Center for Immunity and Immunotherapies, Seattle Children's Research Institute
  • Foundation Title: Children's Guild Association Endowed Chair in Pediatric Immunology Research
  • Research Center: Center for Immunity and Immunotherapies
  • On Staff Since: October 2001
"As a parent and a physician, I am continually amazed by the capacity of our patients and their families to adapt to the challenges of living with a chronic immune-system disease. As a physician-scientist, I am driven by the challenge to make this battle less difficult by whatever means possible now and in the future. And as a graying athlete, I see medical care as the ultimate team sport. Each day, I do my best to build and lead stronger teams teams that more quickly identify a diagnosis and the impact of immune disease and, most importantly, teams that build better and safer treatments and cures for these conditions."

  • Biography

    David J. Rawlings, MD, is chief in the Division of Immunology, overseeing the immunodeficiency clinic at Seattle Childrens Hospital. He is also director of the Center for Immunity and Immunotherapies leading the immunology research programs at Seattle Childrens Research Institute. Dr. Rawlings is professor of pediatrics and adjunct professor in the Department of Immunology at the University of Washington School of Medicine.

    He earned his MD with honors from the University of North Carolina School of Medicine and completed a residency and chief residency in pediatrics at the University of California, San Francisco. He was an intramural research fellow at the NIH and a senior fellow at the Howard Hughes Medical Institute, UCLA. He completed specialty training in pediatric rheumatology and immunology at Childrens Hospital Los Angeles and directed the pediatric rheumatology program at UCLA. Dr. Rawlings has been the recipient of many awards including election to the American Society for Clinical Investigation, Association of American Physicians, and the Childrens Hospital Guild Association Endowed Chair in Pediatric Immunology Research. Dr. Rawlings also co-directs the Northwest Genome Engineering Consortium, a research program funded as part of the NIH Roadmap for Medical Research and focused on developing enzymatic reagents and delivery methods for site specific gene repair in hematopoietic stem cells. His publications include more than 90 peer-reviewed papers and many invited reviews. His primary research interests include dysregulated B cell development and signaling leading to immunodeficiency, autoimmunity or lymphoid malignancies, and the development of gene therapy for primary immune deficiency diseases. His laboratory uses expertise in basic and clinical immunology, signal transduction and lymphocyte developmental biology to understand how altered signals can lead to immunologic disease, with the ultimate goal of developing translational therapies capable of specifically modulating these disorders. He is also actively involved in collaborative studies with the bone marrow transplant team to design and test of new protocols for stem cell transplant in non-malignant disorders. Dr. Rawlings is a member of multiple regional and national organizations, an NIH study section member, and ad hoc reviewer for various grant programs and immunology journals.

    Board Certification(s)

    Pediatric Rheumatology

    Education

    University Of North Carolina School Of Medicine, Chapel Hill, NC

    Residency

    University of California at San Francisco School o, San Francisco, CA

    Fellowship

    Children's Hospital of Los Angeles, Los Angeles, CA
    David Geffen School of Medicine at UCLA, Los Angeles, CA
    Warren Magnuson Clinical Center/National Institute, Bethesda, MD

    Research Description

    My primary research interests include altered lymphoid B cell development and signaling leading to immunodeficiency, autoimmunity or lymphoid malignancies, and the development of gene therapy for primary immune deficiency diseases. My laboratory uses expertise in basic and clinical immunology, signal transduction and lymphocyte developmental biology to understand how altered signals can lead to immunologic disease, with the ultimate goal of developing translational therapies capable of specifically modulating these disorders.

    I am a member of multiple regional and national organizations, an NIH study section member, chairman for the USIDNET XLA patient registry, and ad hoc reviewer for various grant programs and immunology journals. I also co-direct the Northwest Genome Engineering Consortium, a research program funded as part of the NIH Roadmap focused on developing enzymatic reagents and delivery methods for site specific gene repair in hematopoietic stem cells. Northwest Genome Engineering Consortium (NGEC), http://research.seattlechildrens.org/ngec.

    The Immunology research laboratories carry out basic, pre-clinical and clinical research. Primary immunodeficiency disorders (PIDD) represent some of the best candidate disorders for treatment via hematopoietic stem cell gene therapy, and our translational research programs include modeling of novel gene and cellular therapies. Our clinical program also participates in novel clinical trials for non myeloablative hematopoietic stem cell transplant in PIDD.

    Research Focus Area

    Immunology

  • Related Resources

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  • Awards and Honors

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