Selected Publications

1: Doni Jayavelu N, Altman MC, Benson B, Dufort MJ, Vanderwall ER, Rich LM, White MP, Becker PM, Togias A, Jackson DJ, Debley JS. Type 2 inflammation reduces SARS-CoV-2 replication in the airway epithelium in allergic asthma through functional alteration of ciliated epithelial cells. J Allergy Clin Immunol. 2023 Mar 29:S0091-6749(23)00373-1. doi: 10.1016/j.jaci.2023.03.021. Epub ahead of print. PMID: 37001649; PMCID: PMC10052850.

2: Al-Shaikhly T, Murphy RC, Lai Y, Frevert CW, Debley JS, Ziegler SF, Wong K, Jia G, Holweg CTJ, Peters MC, Hallstrand TS. Sputum periostin is a biomarker of type 2 inflammation but not airway dysfunction in asthma. Respirology. 2023 May;28(5):491-494. doi: 10.1111/resp.14491. Epub 2023 Mar 13. PMID: 36914406.

3: Murphy RC, Lai Y, Altman MC, Barrow KA, Dill-McFarland KA, Liu M, Hamerman JA, Lacy-Hulbert A, Piliponsky AM, Ziegler SF, Altemeier WA, Debley JS, Gharib SA, Hallstrand TS. Rhinovirus infection of the airway epithelium enhances mast cell immune responses via epithelial-derived interferons. J Allergy Clin Immunol. 2023 Jan 26:S0091-6749(23)00088-X. doi: 10.1016/j.jaci.2022.12.825. Epub ahead of print. PMID: 36708815.

4: Powell WT, Rich LM, Vanderwall ER, White MP, Debley JS. Temperature synchronisation of circadian rhythms in primary human airway epithelial cells from children. BMJ Open Respir Res. 2022 Oct;9(1):e001319. doi: 10.1136/bmjresp-2022-001319. PMID: 36198442; PMCID: PMC9535174.

5: Hale M, Netland J, Chen Y, Thouvenel CD, Smith KN, Rich LM, Vanderwall ER, Miranda MC, Eggenberger J, Hao L, Watson MJ, Mundorff CC, Rodda LB, King NP, Guttman M, Gale M, Abraham J, Debley JS, Pepper M, Rawlings DJ. IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2. J Exp Med. 2022 Sep 5;219(9):e20220849. doi: 10.1084/jem.20220849. Epub 2022 Aug 8. Erratum in: J Exp Med. 2022 Sep 5;219(9): PMID: 35938988; PMCID: PMC9365875.

6: Vanderwall ER, Barrow KA, Rich LM, Read DF, Trapnell C, Okoloko O, Ziegler SF, Hallstrand TS, White MP, Debley JS. Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replication. Sci Rep. 2022 Apr 28;12(1):6972. doi: 10.1038/s41598-022-10763-2. PMID: 35484173; PMCID: PMC9048621.

7: Al-Shaikhly T, Murphy RC, Parker A, Lai Y, Altman MC, Larmore M, Altemeier WA, Frevert CW, Debley JS, Piliponsky AM, Ziegler SF, Peters MC, Hallstrand TS. Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma. Eur Respir J. 2022 Aug 4;60(2):2101865. doi: 10.1183/13993003.01865-2021. PMID: 35027395; PMCID: PMC9704864.

8: Mast FD, Fridy PC, Ketaren NE, Wang J, Jacobs EY, Olivier JP, Sanyal T, Molloy KR, Schmidt F, Rutkowska M, Weisblum Y, Rich LM, Vanderwall ER, Dambrauskas N, Vigdorovich V, Keegan S, Jiler JB, Stein ME, Olinares PDB, Herlands L, Hatziioannou T, Sather DN, Debley JS, Fenyö D, Sali A, Bieniasz PD, Aitchison JD, Chait BT, Rout MP. Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape. Elife. 2021 Dec 7;10:e73027. doi: 10.7554/eLife.73027. PMID: 34874007; PMCID: PMC8651292.

9: Okoloko O, Vanderwall ER, Rich LM, White MP, Reeves SR, Harrington WE, Barrow KA, Debley JS. Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells. Front Pharmacol. 2021 Nov 19;12:765951. doi: 10.3389/fphar.2021.765951. PMID: 34867390; PMCID: PMC8641911.

10: Barrow KA, Rich LM, Vanderwall ER, Reeves SR, Rathe JA, White MP, Debley JS. Inactivation of Material from SARS-CoV-2-Infected Primary Airway Epithelial Cell Cultures. Methods Protoc. 2021 Jan 7;4(1):7. doi: 10.3390/mps4010007. PMID: 33430421; PMCID: PMC7839057.

11: Bissonnette EY, Lauzon-Joset JF, Debley JS, Ziegler SF. Cross-Talk Between Alveolar Macrophages and Lung Epithelial Cells is Essential to Maintain Lung Homeostasis. Front Immunol. 2020 Oct 15;11:583042. doi: 10.3389/fimmu.2020.583042. PMID: 33178214; PMCID: PMC7593577.

12: Murphy RC, Lai Y, Barrow KA, Hamerman JA, Lacy-Hulbert A, Piliponsky AM, Ziegler SF, Altemeier WA, Debley JS, Gharib SA, Hallstrand TS. Effects of Asthma and Human Rhinovirus A16 on the Expression of SARS-CoV-2 Entry Factors in Human Airway Epithelium. Am J Respir Cell Mol Biol. 2020 Dec;63(6):859-863. doi: 10.1165/rcmb.2020-0394LE. PMID: 32946274; PMCID: PMC7790138.

13: Debley JS, Barrow KA, Rich LM, Singh P, McKone EF, Nichols DP. Correlation between Ivacaftor-induced CFTR Activation in Airway Epithelial Cells and Improved Lung Function: A Proof-of-Concept Study. Ann Am Thorac Soc. 2020 Aug;17(8):1024-1027. doi: 10.1513/AnnalsATS.202001-082RL. PMID: 32421352; PMCID: PMC7787006.

14: Shubin NJ, Clauson M, Niino K, Kasprzak V, Tsuha A, Guga E, Bhise G, Acharya M, Snyder JM, Debley JS, Ziegler SF, Piliponsky AM. Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition. Mucosal Immunol. 2020 Jul;13(4):584-594. doi: 10.1038/s41385-020-0271-0. Epub 2020 Feb 26. PMID: 32103153; PMCID: PMC7312418.

15: White MP, Kolstad TK, Elliott M, Cochrane ES, Stamey DC, Debley JS. Exhaled Nitric Oxide in Wheezy Infants Predicts Persistent Atopic Asthma and Exacerbations at School Age. J Asthma Allergy. 2020 Jan 7;13:11-22. doi: 10.2147/JAA.S227732. PMID: 32021309; PMCID: PMC6954861.

16: Altman MC, Lai Y, Nolin JD, Long S, Chen CC, Piliponsky AM, Altemeier WA, Larmore M, Frevert CW, Mulligan MS, Ziegler SF, Debley JS, Peters MC, Hallstrand TS. Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling. J Clin Invest. 2019 Nov 1;129(11):4979-4991. doi: 10.1172/JCI126402. PMID: 31437129; PMCID: PMC6819127.

17: Reeves SR, Barrow KA, Kolstad TK, White MP, Rich LM, Wight TN, Debley JS. Fibroblast gene expression following asthmatic bronchial epithelial cell conditioning correlates with epithelial donor lung function and exacerbation history. Sci Rep. 2018 Oct 25;8(1):15768. doi: 10.1038/s41598-018-34021-6. PMID: 30361541; PMCID: PMC6202408.

18: Reeves SR, Barrow KA, White MP, Rich LM, Naushab M, Debley JS. Stability of gene expression by primary bronchial epithelial cells over increasing passage number. BMC Pulm Med. 2018 May 29;18(1):91. doi: 10.1186/s12890-018-0652-2. PMID: 29843677; PMCID: PMC5975426.

19: James RG, Reeves SR, Barrow KA, White MP, Glukhova VA, Haghighi C, Seyoum D, Debley JS. Deficient Follistatin-like 3 Secretion by Asthmatic Airway Epithelium Impairs Fibroblast Regulation and Fibroblast-to-Myofibroblast Transition. Am J Respir Cell Mol Biol. 2018 Jul;59(1):104-113. doi: 10.1165/rcmb.2017-0025OC. PMID: 29394092; PMCID: PMC6039878.

20: Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JS. Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function. J Allergy Clin Immunol. 2018 Aug;142(2):451-459. doi: 10.1016/j.jaci.2017.10.004. Epub 2017 Oct 26. PMID: 29106997; PMCID: PMC5951761.

21: Reeves SR, Kolstad T, Lien TY, Herrington-Shaner S, Debley JS. Fibroblast- myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children. Respir Res. 2015 Feb 13;16(1):21. doi: 10.1186/s12931-015-0185-7. PMID: 25849331; PMCID: PMC4333174.

22: Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JS. Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components. J Allergy Clin Immunol. 2014 Sep;134(3):663-670.e1. doi: 10.1016/j.jaci.2014.04.007. Epub 2014 May 27. PMID: 24875618; PMCID: PMC4149938.

23: Elliott M, Heltshe SL, Stamey DC, Cochrane ES, Redding GJ, Debley JS. Exhaled nitric oxide predicts persistence of wheezing, exacerbations, and decline in lung function in wheezy infants and toddlers. Clin Exp Allergy. 2013 Dec;43(12):1351-61. doi: 10.1111/cea.12171. PMID: 24261945; PMCID: PMC3839057.

24: Miazgowicz MM, Elliott MS, Debley JS, Ziegler SF. Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells. J Inflamm Res. 2013;6:53-61. doi: 10.2147/JIR.S42381. Epub 2013 Mar 24. PMID: 23576878; PMCID: PMC3617816.

25: Lee HC, Headley MB, Loo YM, Berlin A, Gale M Jr, Debley JS, Lukacs NW, Ziegler SF. Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection. J Allergy Clin Immunol. 2012 Nov;130(5):1187-1196.e5. doi: 10.1016/j.jaci.2012.07.031. Epub 2012 Sep 13. PMID: 22981788; PMCID: PMC4284103.

26: Lopez-Guisa JM, Powers C, File D, Cochrane E, Jimenez N, Debley JS. Airway epithelial cells from asthmatic children differentially express proremodeling factors. J Allergy Clin Immunol. 2012 Apr;129(4):990-7.e6. doi: 10.1016/j.jaci.2011.11.035. Epub 2012 Jan 9. PMID: 22227417; PMCID: PMC3604976.

27: Debley JS, Stamey DC, Cochrane ES, Gama KL, Redding GJ. Exhaled nitric oxide, lung function, and exacerbations in wheezy infants and toddlers. J Allergy Clin Immunol. 2010 Jun;125(6):1228-1234.e13. doi: 10.1016/j.jaci.2010.03.023. Epub 2010 May 11. PMID: 20462633; PMCID: PMC2879468.

28: Debley JS, Ohanian AS, Spiekerman CF, Aitken ML, Hallstrand TS. Effects of bronchoconstriction, minute ventilation, and deep inspiration on the composition of exhaled breath condensate. Chest. 2011 Jan;139(1):16-22. doi: 10.1378/chest.10-0101. Epub 2010 Apr 9. PMID: 20382713; PMCID: PMC3014689.

29: Debley JS, Hallstrand TS, Monge T, Ohanian A, Redding GJ, Zimmerman J. Methods to improve measurement of cysteinyl leukotrienes in exhaled breath condensate from subjects with asthma and healthy controls. J Allergy Clin Immunol. 2007 Nov;120(5):1216-7. doi: 10.1016/j.jaci.2007.06.029. Epub 2007 Jul 26. PMID: 17655919.

30: Debley JS, Carter ER, Gibson RL, Rosenfeld M, Redding GJ. The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study. J Pediatr. 2005 Aug;147(2):233-8. doi: 10.1016/j.jpeds.2005.03.055. PMID: 16126056.

31: Debley JS, Smith JM, Redding GJ, Critchlow CW. Childhood asthma hospitalization risk after cesarean delivery in former term and premature infants. Ann Allergy Asthma Immunol. 2005 Feb;94(2):228-33. doi: 10.1016/S1081-1206(10)61300-2. PMID: 15765737.

32: Debley JS, Redding GJ, Critchlow CW. Impact of adolescence and gender on asthma hospitalization: a population-based birth cohort study. Pediatr Pulmonol. 2004 Dec;38(6):443-50. doi: 10.1002/ppul.20108. PMID: 15690559.